Peptinov’s vaccine approach can be applied to many non-infectious diseases (auto-immune diseases, cancer, chronic pain). It has the potential to provide a complementary approach to monoclonal antibodies in large populations with limited access to biologics. The effect duration of Peptinov’s vaccines is temporary (3-4 months). Consequently the vaccines must be administered several times per year. Their production cost is very low.
Peptinov’s active inmmunization approach
Peptinov’s breakthrough active immunization approach uses tailored peptide-based vaccines, derived from target self proteins.
These peptides which are selected and designed using an array of bioinformatics tools (trade secret) are designed to induce the production of antibodies directed against the targeted proteins after immunization. The produced antibodies neutralize the biological activity of the target protein.
In doing so, Peptinov’s vaccines have a similar action compared to monoclonal antibodies.
This vaccine approach present several advantages:
- very low production costs
- ease of use
- potentially no resistance to treatment.
Peptinov’s anti-IL-6 vaccine is the most advanced product in the R&D pipeline and is currently entering regulatory pre-clinical development (toxicology studies).
Capini et al. Active immunization against murine TNFα peptides in mice: generation of endogenous antibodies cross-reacting with the native cytokine and in vivo protection. Vaccine. 2004;22(23-24):3144-53. PMID: 15297057.
Bertin-Maghit et al. Improvement of collagen-induced arthritis by active immunization against murine IL-1beta peptides designed by molecular modelling. Vaccine. 2005;23(33):4228-35. PMID: 16005738.
Ratsimandresy et al. Active immunization against IL-23p19 improves experimental arthritis. Vaccine. 2011;29(50):9329-36. PMID: 22008816.
Desallais et al. Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis. Arthritis Res Ther. 2014;16(4):R157. PMID: 25059342
Desallais et al. Immunization against an IL-6 peptide induces anti-IL-6 antibodies and modulates the Delayed-Type Hypersensitivity reaction in cynomolgus monkeys. Scientific Reports. 2016 Jan 19;6:19549. PMID: 26782790